Biolocalization studies

The coordination chemistry of rhenium is better known and easier to handle than that of technetium and, in view of their expected analogies, the former metal can be used for nonradioactive model studies for technetium. In addition, Re and Re display attractive properties (Section 1) for nuclear medicine. The biolocalizations of analogous Re and Tc compounds can also be similar. Hence, the Tc and the Re (or Re) radionuclides constitute a potential matched pair for diagnosis and therapy. ... 

EPR has been a useful in-vivo probe of vanadium metabolism. One of the earliest experiments to study biolocalization of V(IV) species was reported in 1980. After i.p. administration of sodium metavanadate for 3 days, V(IV) species were detected by EPR in the subcellular fiaction of rat liver. Using the older structural correlation between Ao and g values, flie detected species was proposed to possess mostly O4 coordination and be present in a protein-bound form [92]. 

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