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Bioisosteric replacement nonclassical

Bioisosteric Replacement and Nonisosteric Bioanalogs (Nonclassical Bioisosteres), 689... [Pg.687]

BIOISOSTERIC REPLACEMENT AND NONISOSTERIC BIOANALOCS (NONCLASSICAL BIOISOSTERES)... [Pg.689]

Figure 9.3 Structural analogs of nonclassical bioisosteric replacement. Figure 9.3 Structural analogs of nonclassical bioisosteric replacement.
The oldest example of the use of nonclassical isosteres involves the replacement of the carboxamide in foUc acid by sulfonamide, to give the sulfanilamides. Diaminopyrimidines, as antimalarial agents, are also based on folate isosterism, in addition to the exploitation of auxiliary binding sites on dihydrofolate reductase. This concept of nonclassical isosteres or bioisosteres — that is, moieties that do not have the same nnmber of atoms or identical electron structure — is really the classical structure modification approach. [Pg.139]

Replacement of the methyl ester moiety of the muscarinic partial agonist arecoline (16) by the putative nonclassical bioisosteric 1,2,4-oxadiazole ring system (18), where R = un-... [Pg.694]

See other pages where Bioisosteric replacement nonclassical is mentioned: [Pg.227]    [Pg.690]    [Pg.46]    [Pg.94]    [Pg.97]    [Pg.118]   
See also in sourсe #XX -- [ Pg.51 , Pg.51 , Pg.52 ]



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