Bioinformatics, small molecule drug development

The drug target universe expands considerably if we expand our analysis to include biological targets for which medicinal chemists have developed small-molecule leads. Unlike the bioinformatics community which has developed a wealth of public databases to assemble and disseminate protein and genomic sequences, medicinal chemistry structure-activity relationship (SAR) data is... 

To support drug discovery efficiently, the biological information derived in bioinformatics needs to be combined with chemical data in order to facilitate the identification of lead structures and the development of small molecules as active pharmaceuticals. To this end, different databases need to be brought together for the integration of disparate re-sults.t ... 

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