Biocompatible gels, applications

Al-modified silica had a strong interaction with PAM (Ye et al., 2014). The peroxide surface of SNPs was obtained when irradiated by a °Co y-ray, and subsequent polymerization of AA produced silica-based hydrogels, which had no residues of initiators or crosslinkers therefore, they can be used in biocompatible gel applications (Koo et al., 2012). 

As mentioned above, the preparation of nanogels by addition reactions of functional macromolecular precursors is mainly used for biomedical applications. Thus, the choice of synthetic precursors for microgel formation is restricted to biocompatible materials. Moreover, as most applications are in drug delivery, the molecular weight of the gel precursors should be below the threshold for renal clearance, a value that depends on the molecular architecture and chemical nature of the polymer but that is usually smaller than 30kDa, which is set as the limit for linear PEG [97], Polymers that are mostly used and thus presented in more detail here are PEG, poly(glycidol) (PG), and polyethylene imine) (PEI). 

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