Biocatalyzed Reactions on Polymeric Supports Enzyme-Labile Linker Groups

Biocatalyzed reactions on polymeric supports Enzyme-labile linker groups 

Reinhard Reents, Duraiswamy Jeyaraj and Herbert Waldmann 

In principle, linker groups are polymer-enlarged versions of blocking functions used in regular solution-phase chemistry. Therefore, enzymatic transformations that may be employed for the removal of protecting groups in solution, in principle may also open up alternative opportunities for releasing compounds from polymeric supports. The linkers developed so far can be divided into exo- and endo-linkers (Fig. 10.1) cleavable by exo- respectively endo-enzymes, as proposed by Flitsch et al. [6]. 

Copyright 2003 WILEY-VCH Verlag GmbH Co. KGaA, Weinheim ISBN 3-527-30630-7 

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I 7 0 Biocatalyzed reactions on polymeric supports Enzyme-labile linker groups... 

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