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Biocatalyst metal-catalyzed hydrogenation

The award of the Nobel Prize in Chemistry in 2001 to William R. Knowles and Ryoji Noyori for their work on metal-catalyzed enantioselective hydrogenation reactions and to K. Barry Sharpless for his work on catalyzed enantioselective oxidation reactions was a landmark in chiral catalysis studies. Enzymes and biocatalysts have also played a pivotal role as asymmetric catalysts [16]. [Pg.311]

Transition metal catalysts and biocatalysts can be combined in tandem in very effective ways as shown by the following example (Scheme 2.21). An immobilized rhodium complex-catalyzed hydrogenahon of 46 was followed by enzymatic hydrolysis of the amide and ester groups of 47 to afford alanine (S)-9 in high conversion and enanhomeric excess. Removal of the hydrogenation catalyst by filtration prior to addition of enzyme led to improved yields when porcine kidney acylase 1 was used, although the acylase from Aspergillus melleus was unaffected by residual catalyst [23]. [Pg.32]


See other pages where Biocatalyst metal-catalyzed hydrogenation is mentioned: [Pg.50]    [Pg.271]    [Pg.142]    [Pg.643]    [Pg.186]    [Pg.229]    [Pg.419]    [Pg.630]    [Pg.2]   
See also in sourсe #XX -- [ Pg.271 ]




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Biocatalyst

Hydrogen catalyzed

Hydrogen metal catalyzed

Hydrogenation, catalyzed

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