Biocatalysis reductive amination

Bommarius, A. S., Drauz, K., Hummel, W., Kula, M.-R. and Wandrey, C. Some New Developments in Reductive Amination with Cofactor Regeneration. Biocatalysis 1994, 10, 37 7. 

Another example, from the Pfizer portfolio, of successful incorporation of biocatalysis to make functional group interconversions (FGIs) more efficient in API synthesis is in a program for a smoothened (SMO) receptor inhibitor [17], Introduction of a transaminase-catalyzed stereoselective reductive amination of a 4-piperidone 4 with concurrent dynamic kinetic resolution (DKR) gave amine 5 (Scheme 7.2), resulting in the highly efficient incorporation of two chiral centers in a single step. 

The enz5miatic, as5unmetric reduction of carbonyl compounds is described, emphasizing directed evolution and protein engineering, to develop novel biocatalysts for reduchon and reductive amination processes, with isolated enz5unes and whole-cell biocatalysis. 

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