Biocatalysis precipitation driven

Figure 12.1 Precipitation-driven biocatalysis, where the dissolution of the substrates and the enzyme-catalyzed reaction happen with consequent precipitation of the products.

The solid-to-solid approach clearly combines the good rates observed in aqueous solution, with the high yields typical of biocatalysis in organic solvents. Many successful examples of precipitation-driven reactions for the synthesis of peptides have been published in recent years (Table 12.3). 

Table 12.4 Precipitation-driven biocatalysis for the synthesis of peptides, catalyzed by proteases, in the presence of organic solvents.

Uhjn RV, Janssen AEM, Moore BD et al. (2001) Predicting when precipitation-driven synthesis is feasible applications to biocatalysis. Chem Eur J 7 2089-2098. 

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