Bioavailability testing criteria

Although different standards are set for different classes or types of drugs, the general bioavailability standard is an upward or downward variation of no more than 20%. Most generic versions tested to date have demonstrated plasma levels within 3% to 5% of the innovator drug. Sentiment is growing for an achievable +10% bioavailability criterion. 

Figure 4. Bioavailability of monoferric phytate baked into bread. Rats were the test species and change in hemoglobin concentration during a 2-week repletion period was bioassay criterion.

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