Bioaffinity receptors, examples

Enz)mies, inhibitors, cofactors, nucleic acids, hormones or cell chromatography can also be utilized as ligands in bioaffinity chromatography types. Examples of these methods include Receptor Affinity Chromatography and DNA Affinity Chromatography [21]. 

An interesting but underutilized approach to screening combinatorial libraries combines bioaffinity-based isolation and mass spectrometric identification. This approach requires the characterization of a drug to a macromolecular receptor such as an enzyme. This immobilized receptor can be conveniently packed into a chromatographic column [41], although configurations that do not use a column have also been reported [42]. An example of the latter, pulsed ultra-filtmtion (PUF) has been reported [43] and is illustrated in Fig. 12. 

---