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Bioactive conformation 420 Subject

Conformational restriction played an important role in the discovery that water induces the bioactive conformation of CsA. Cyclosporin A (Sandimmune , CsA, (23.37), Fig. 23.7), is a major drug for preventing rejection of transplanted human organs and has been the subject of many synthetic, conformational and mechanism of action studies. To produce immunosuppression, CsA first binds to cyclophilin A (CyP A), a peptidyl prolyl cis-trans isomerase (PPIase), to form the CsA-CyP complex, which then binds to and inhibits calcineuiin (CaN), a calmodulin-dependent serine/threonine protein phosphatase, thereby inhibiting interleukin-2 (IL-2) synthesis. ... [Pg.378]

See other pages where Bioactive conformation 420 Subject is mentioned: [Pg.163]    [Pg.723]    [Pg.384]    [Pg.51]    [Pg.57]    [Pg.658]    [Pg.415]    [Pg.1235]    [Pg.408]    [Pg.152]    [Pg.355]    [Pg.336]   


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Bioactive conformation

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