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Bioactive agents, chemical stability

In an earlier section, the potential for a water-soluble substance to deliquesce was discussed. The emphasis here is on less obvious effects of moisture on solid dosage forms, and three associated areas that link to information presented earlier in this article are discussed 1) moisture-induced changes in the state of the solid 2) the effect of moisture on the performance of excipients in the manufacture of compressed tablets and 3) the chemical stability of bioactive agents alone and in combination with excipients. [Pg.2379]

Despite recent advances in understanding the influence of moisture on the physical state of the solid, it is perhaps the effect of sorbed moisture on the chemical stability of moisture-sensitive drugs that is most important, particularly because many new bioactive agents are expensive moisture-sensitive proteins. [Pg.2380]

See other pages where Bioactive agents, chemical stability is mentioned: [Pg.367]    [Pg.128]    [Pg.2380]    [Pg.1171]    [Pg.442]    [Pg.367]    [Pg.106]    [Pg.182]    [Pg.153]    [Pg.135]    [Pg.146]    [Pg.12]    [Pg.572]    [Pg.249]    [Pg.15]    [Pg.257]    [Pg.9]    [Pg.91]    [Pg.343]    [Pg.263]    [Pg.154]    [Pg.231]    [Pg.10]    [Pg.232]    [Pg.540]    [Pg.483]    [Pg.232]    [Pg.60]    [Pg.377]    [Pg.99]   
See also in sourсe #XX -- [ Pg.2380 ]



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