Mixed bioactivation mechanisms

Antimicrobial Edible films were prepared from natural fiber of pectin and other food hydrocolloids for food packaging or wrapping by extrusion followed by compression or blown film method. Microscopic analysis revealed a well mixed integrated structure of extruded pellets and an even distribution of the synthetic hydrocolloid in the biopolymers. The resultant composite films possess the mechanical properties that are comparable to films cast from most natural hydrocolloids that consumed as foods or components in processed foods. The inclusion of polyethylene oxide) alters the textures of the resultant composite films and therefore, demonstrating a new technique for the modification of film properties. The composite films were produced in mild processing conditions, thus, the films are able to protect the bioactivity of the incorporated nisin, as shown by the inhibition of Listeria monocytogenes bacterial growth by a liquid incubation method. 

B Reductive bioactivation of omeprazole Mixed Bioactivation Mechanisms... 

C I Mechanism of toxicolp damage. Mixed function oxidases (MFOs) appear to bioactivate... 

Mechanisms of liver injury have been divided into two categories intrinsic and idiosyncratic. Intrinsic injury may lead to steatosis, necrosis, cholestasis, or a mixed form of damage, often with minimal inflammation (Sturgill and Lambert, 1997). Intrinsic liver injury is a predictable, reproducible, dose-dependent reaction to a toxicant (Dahm and Jones, 1996 Sturgill and Lambert, 1997 Zimmerman, 1999 Pineiro-Carrero and Pineiro, 2004). A threshold dose exists for xenobiotics causing intrinsic liver injury. There is commonly a predictable latent period between the time of exposure and clinical evidence of liver injury. This type of liver injury accounts for the vast majority of toxic liver injury and is often caused by reactive products of xenobiotic metabolism, most commonly electrophiles and free radicals. A few drugs cause intrinsic liver injury without bioactivation. An abbreviated summary of mechanisms of intrinsic liver injury is illustrated in Figure 42.1. 

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