BINOL-Phosphates as Catalysts for the Strecker Reaction

The BINOL phosphate catalyzed cyanide addition was also examined as a three-component-Strecker reaction of an acetophenone derivative with an aniUne component only poor stereoselectivities (20-40% ee) were obtained in reasonable yields (73-81%) [49]. 

The group ofTsogoeva discovered that BINOL-phosphate catalyst 93 can promote the enantioselective addition of TMSCN to aliphatic hydrazones 92 (Table 30.12) [50]. The so-formed a-hydrazino nitriles 95 can be readily transformed via acidic hydrolysis into biologically and synthetically important a-hydrazino acids. In general, N-p-N02-benzoyl-protected ahphatic hydrazones 92 could be converted in good enantioselectivities (71-93% ee). The yields showed inconsistency, but 

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