Binding sites, introduction catalytic groups

In a rational approach to the reproduction of enzyme-like catalytic behavior with a synthetic polymer one should use, therefore, a two-step plan (1) fabrication of binding sites on a suitable macromolecular framework (2) introduction of groups to provide an environment of specific functional side chains that facilitate formation of the transition state in the catalytic step. 

Introduction of catalytic groups or cofactors at the binding sites... 

---