Binding site heterogeneity

Duggan, MJ and Stephenson, FA (1988) Benzodiazepine binding site heterogeneity in the purified GABAa receptor. Eur. J. Pharmacol. 154 293-298. 

Figure 15.2 Depiction of the binding site heterogeneity of a molecular imprinted polymer.

Fig. 2 Representation of binding sites heterogeneity high affinity site in macropore (A) and micropore (F), and lower affinity sites (B) in macropore, (C) trapped template, (E) embedded site, (D) highest affinity site with shape selectivity from polymer. Reproduced from [12] with permission of The royal Society of Chemistry...

Tipping, E., Backes, C.A. and Hurley, M.A. (1988) The complexation of protons, aluminium and calcium by aquatic humic substances a model incorporating binding-site heterogeneity and macroionic effects. Water Res., 22(5), 597-611. 

Aluminum and Calcium by Aquatic Humic Substances A Model Incorporating Binding Site Heterogeneity and Macro-Ionic Effects, Water Res. 22, 579-611. 

For noncovalent-imprinted polymers, binding site heterogeneity (/polyclonality) arises largely from the preequilibria between template and different template-monomer complexes in the prepolymerization mixture ... 

Because MIA probes only the sites of the MIP with strongest affinity for the probe, significant binding site heterogeneity is not detrimental. Provided the highest affinity sites exhibit good selectivity, the features of the rest of the MIP matrix are... 

Binding sites heterogeneity Extensive nonspecific binding Slow mass transfer Bleeding of template... 

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