Binding single-component diffusion

Single component diffusion and binding. Figure 4 shows four cases which were simulated to observe the effects of immobilization in hydrogel and reduction of adsorbent particle size. Case (a) represents a freely suspended adsorbent particle of radius 1.1 mm. Case (b) represents the same size particle immobilized in a hydrogel bead of 2.8 mm. In case (c), the same adsorbent particle as in cases (a) and (b) was assumed to be crushed to 80 smaller particles which were immobilized within a hydrogel bead of radius 2.8 mm. Case (d) represents the extreme situation in which the adsorbent particle was crushed to fine powder such that the total number of particles within the immobilized bead may be regarded as infinite. This is also... 

Given the very small amount of protein present in a single crystal relative to the concentrations of DCL components, it is clear that amplification in the usual sense cannot occur. It is conceivable, however, that the protein structure influences equilibrium distribution of hydrazones in microcosm within the crystal. Conversely, it is possible that any DCC equilibrium is irrelevant, and that the hydrazone binding being observed by X-ray diffraction is due to a diffusion equilibrium of essentially static components between solution and solid state. 

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