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Biguanides elimination

The results of hemodialysis in biguanide-induced lactic acidosis are variable. Metformin and buformin are dialy-sable, but phenformin is poorly eliminated. Successful continuous venovenous hemofiltration has been reported (81). [Pg.373]

Biguanide toxicity is primarily managed by supportive means. Its elimination from the body could be enhanced by dialysis or enhancing excessive urination. [Pg.272]

Treatment with biguanides should begin with a small dose of medication and a progressive build-up over a 1-2-week period (Asmal and Marble, 1984). As far as metformin is concerned, its elimination half-life requires a dosage interval of about 8 h or more (three times or twice a day) which will not induce accumulation when renal function is normal (Pentikainen et al., 1979). [Pg.142]

Metformin has an absolute oral bioavailability of about 50-60% of the dose after oral application of a single dose. Deconvolution analysis showed that after a short lag-time, the available remainder of the oral dose was absorbed at an exponential rate over about 6 h (Tucker et al., 1981). The bioavailability of phenformin seems to be more variable but also in the range of about 50% (Beckmann, 1968 Travis and Sayers, 1970). In general, absorption of biguanides is slower than their elimination, hence the plasma levels follow flip-flop kinetics (Pentikainen et al., 1979). [Pg.142]

Metformin is slowly and incompletely absorbed and rapidly eliminated without hepatic metabolism. This pharmacokinetic profile may make drug accumulation and lactic acidosis less likely to occur with metformin than with other biguanides. Sales of the longer-acting biguanide phenformin (10), for instance, which is metabolized in the liver by aromatic... [Pg.21]


See other pages where Biguanides elimination is mentioned: [Pg.80]    [Pg.1428]    [Pg.278]    [Pg.396]    [Pg.1128]    [Pg.278]    [Pg.281]    [Pg.303]    [Pg.144]    [Pg.84]    [Pg.317]    [Pg.927]    [Pg.124]    [Pg.305]   
See also in sourсe #XX -- [ Pg.143 ]




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