Bidirectional peptide synthesis

CVclic Peptides. Polymer supp s aid in the synthesis of cyclic peptides (1.10.131. A recent example is the synthesis of cyc/o-(Gly-His)3 2% crude chromatographic yield in a 1% cross-linked, 0.20 mmol/g aminomethyl resin by a bidirectional method (1401. The actual yield of die cyclization step (Scheme 13) is unknown, because the ovoall yield includes the yields of initial attachrnent, five deprotection-coupling steps, and cleavage from the resin. Most importantly, the cyclic hexapeptide contained no detectable amounts of linear or oligomoic cyclic peptides. 

Fig. 11. The peptide cyclization in polymer phase after bidirectional synthesis of the linear precursor...

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