2,2 -Biaryls dihydro

A diastereoselective imine alkylation and a palladium-catalysed biaryl coupling were important steps in the diastereoselective synthesis of 6,7-dihydro-5//-dibenz[c,e]azepines (Scheme 7) starting from (R)-l-(2-methoxyphenyl)ethylamine. Selection for the... 

Uses of bases of this type, such as DBU and DBN have been reviewed [15] and more recently they have been used as stoichiometric bases in the synthesis of 2H-isoindoles [ 16],biaryl thioethers [17],phthalocyanines [18] and the related macrocyclic compounds [18], 2,4-dioxo-l,2,3,4-tetrahydroquinazolines [19], dihydro alanine-containing peptides [20] and [[pyrazolylmethyl)amino]-propyl azepinones and -pyrrolidinones [21]. Chiral DBU/DBN-related molecules have also been synthesized which were fovmd to be useful as catalysts in an asymmetric Michael reaction [22]. 

The Strecker reaction of a dial with an amine and hydrogen cyanide, to produce a cyclic a,a -dicyanoamine, involves HCN addition to a cycUc imino nitrile intermediate as the final step. A highly diastereoselective synthesis of dihydro-5//-dibenz[c, ]azepines (80) from the biphenyldicarboxaldehyde exploits the chiral twist of the biaryl axis to achieve stereoselection. ... 

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