1,1 -biaryl-2,2 -dimethanol BAMOL

Yamamoto and Rawal developed a novel axially chiral l,l -biaryl-2,2 -dimethanol (BAMOL) scaffold (32) (Figure 2.28) as a catalyst for the hetero Diels-Alder... 

Rawal and Yamamoto visualized that axially chiral l,l -biaryl-2,2 -dimethanols (BAMOLs) 25a and 25b possessing the 4-fluoro-3,5-dimethylphenyl and 4-fluoro-3,5-diethylphenyl groups, respectively, could activate the aldehyde carbonyl through hydrogen bonding and thus act as a prominent catalyst for the enantiose-lective hetero-Diels-Alder reaction of an aminosiloxydiene with a wide variety of aldehydes as illustrated in Scheme 7.44 [69]. 

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