Nifedipine Betaxolol

Nifedipine 10 mg three times daily did not alter the pharmacokinetics of atenolol 100 mg daily, betaxolol, metoprolol 100 mg twice daily 47 or propranolol 80 mg twice daily. A single-dose study also found no pharmacokinetie interaetion between nifedipine and atenolol. However, another study found that nifedipine 10 mg three times daily eaused an inerease in the peak plasma level and AUC of propranolol 80 mg twiee daily of 56% and 23%, respectively. Another study found that the absorption of a single-dose of propranolol appeared to be faster, leading to higher initial eoncentrations, when it was given after nifedipine. Regardless of the pharmacokinetic changes, none of these studies in healthy subjeets found any adverse haemodynamic effects from the eombination of nifedipine and these beta blockers. - ... 

VinceneuxI Canal M, Donart Y, Roux A, Cascio B, Oroflamma B, Larribaud J, Flouvat B, Carbon C. Fharmacokinetic and pharmacodynamic interactions between nifedipine and Topranolol or betaxolol. IntJClin Pharmacol Ther Toxicol (1986) 24,153-8. 

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