Betamethasone pharmacokinetics

Pharmacokinetic studies in dogs demonstrated a 3.5-fold increase in oral bioavailability of phenytoin when administered as the disodium phosphate prodrug versus sodium phenytoin [54]. A few additional examples of investigations with this strategy include the steroids betamethasone [55] and hydrocortisone [56], HIV protease inhibitors [57], and the anticancer drug etoposide [58,59]. Comprehensive reviews of this strategy are also available [52,60,61]. 

Loo, J.C., et al. 1981. Pharmacokinetic evaluation of betamethasone and its water soluble phosphate ester in humans. Biopharm Drug Dispos 2 265. 

Garg, V. Jusko, W.J. Effects of indomethacin on the pharmacokinetics and pharmacodynamics of prednisolone in rats. J.Pharm.Sci., 1994, 83, 747-750 [rat plasma extracted corticosterone, prednisolone, prednisone betamethasone is IS]... 

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