Benzylpenicillin penicillin meningitis

When chlortetracycUne originally became available it was tested as a potential treatment for meningitis. In patients with pneumococcal meningitis it was shown that benzylpenicillin one million units, intramuscularly every 2 hours was more effective than the same regimen of penicillin with chlortetracycUne 500 mg intravenously every 6 hours. Out of 43 patients given penieillin alone, 70% recovered, compared with only 20% in another group of 14 essentially similar patients v o had received both antibacterials. ... 

Another report about the treatment of pneumococcal meningitis with intramuscular or intravenous penicillin and intravenous tetracyclines (chlo-rtetracycline, oxytetracycUne, tetracycline) confirmed that the mortality was much lower in those given only penicillin, rather than the combination of penicillin and a tetracycline. fri the treatment of scarlet fever (Group A beta-haemolytic streptococci), no difference was seen in the initial response to treatment with penicillin (oral procaine benzylpenicillin) and chlortetracycUne or the penicillin alone, but spontaneous re-in-feetion occurred more frequently in those who had received both antibacterials. ... 

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