Benzyloxycarbonyl

Tpte [2-[(4-tritylphenyl)thio]ethyl] Z = Cbz benzyloxycarbonyl protecting group... [Pg.438]

The reactivity of an ammo group is suppressed by converting it to an amide and ammo groups are most often protected by acylation The benzyloxycarbonyl group O... [Pg.1137]

C6H5CH2OC—) IS one of the most often used ammo protecting groups It is attached by acylation of an ammo acid with benzyloxycarbonyl chloride... [Pg.1137]

Lysine reacts with two equivalents of benzyloxycarbonyl chio ride to give a derivative containing two benzyloxycarbonyl groups What is the structure of this compound /... [Pg.1137]

Just as It IS customary to identify individual ammo acids by abbreviations so too with protected ammo acids The approved abbreviation for a benzyloxycarbonyl group IS the letter Z Thus N benzyloxycarbonylphenylalanine is represented as... [Pg.1137]

Another name for the benzyloxycarbonyl group is carbobenzoxy This name and Its abbreviation Cbz are often found in the older lit erature but are no longer a part of lUPAC nomenclature... [Pg.1137]

Alternatively the benzyloxycarbonyl protecting group may be removed by treat ment with hydrogen bromide m acetic acid... [Pg.1138]

Ammo protecting groups include benzyloxycarbonyl (Z) and tert butoxy carbonyl (Boc)... [Pg.1151]

Hydrogen bromide may be used to remove either the benzyloxycarbonyl or tert butoxycarbonyl protecting group The benzyloxycarbonyl protect mg group may also be removed by catalytic hydrogenolysis... [Pg.1151]

JCS2689) and 5-bromomethylpyrimidine (458) and diethyl benzyloxycarbonyl-aminomalonate (459) give initially, diethyl a-benzyloxycarbonylamino-a-(pyrimidin-5-ylmethyOmalonate (460) which can be degraded to 2-amino-3-(pyrimidin-5 -yl)propionic acid (461) (65JHCl>. [Pg.103]

AcOH, HBr, 10°, 10 min, 70% yield. Phthaloyl or trifluoroacetyl groups on amino acids are stable to these conditions benzyloxycarbonyl (Cbz) or /-butoxycarbonyl (BOC) groups are cleaved. [Pg.246]

I. Allyl bromide, Aliquat 336, NaHC03, CH2CI2, 83% yield. The carboxylic acid group of Z-serine (Z = Cbz = benzyloxycarbonyl) is selectively es-terified without affecting the alcohol. [Pg.248]

The Moz group is more readily cleaved by acid than is the benzyloxycarbonyl or BOC group.The section on benzyl carbamates should be consulted since many of the methods for formation and cleavage should be applicable to the Moz group as well. [Pg.339]

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