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3- Benzyl-2-pyrazinamine

Pyrazinamine (27, R = H) gave 3-benzyl-2-pyrazinamine (27, R = CH2Ph) (pre-fonned PhCHjLi, THF, 0°C, N2, 1 h 32%) 2-acetamidopyrazine (28, R = H) gave 2-acetamido-3-benzylpyrazine (28, R = CH2Ph) (37%) and other analogues were made similarly without added oxidant. ... [Pg.81]

Benzyl-5-p-(trifluoromethyl)phenyl-2-pyrazinamine from its 1-oxide (256, R = CF3) [Raney Ni catalyst (20 X wt of substrate), EtOH, reflux, H2 (atm), 90 min 83% it seems doubtful if the H2 plays any role other than that of an inert atmosphere] 73 also 3-benzyl-5-p-methoxyphenyl-2-pyrazinamine from its 1-oxide (256, R = OMe) (likewise but at 20°C, 4 days >90%).397... [Pg.232]

Benzyl-5-methyl-2-pyrazinamine 1-oxide (275) gave 2-acetoxy-5-benzyl-6-di-acetylamino-3-methylpyrazine (276) (Ac20—AcOK, reflux, 10 min 67%).883... [Pg.235]

Benzyl-6-methoxy-5-methyl-2-pyrazinamine 2-Benzyl-3-methoxy-6-methyl pyrazine 2-Benzyl-6-methoxy-3-methylpyrazine... [Pg.372]

A key intermediate required for the synthesis of colenterazine was reported by Adamczyk et al. [46]. Treatment of 3-benzyl-5-bromo-2-pyrazinamine (77) with commercially available 4-methoxyphenylboronic acid in the presence of dppb and Pd(PhCN)2Cl2 afforded 3-benzyl-5-(4-methoxyphenyl)-2-pyrazinamine (78) in 88% yield [46]. [Pg.447]

See other pages where 3- Benzyl-2-pyrazinamine is mentioned: [Pg.81]    [Pg.37]    [Pg.81]    [Pg.274]    [Pg.373]    [Pg.373]    [Pg.373]    [Pg.37]    [Pg.37]    [Pg.274]    [Pg.372]    [Pg.372]    [Pg.373]    [Pg.373]    [Pg.373]   
See also in sourсe #XX -- [ Pg.81 ]

See also in sourсe #XX -- [ Pg.81 ]



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2-Pyrazinamine

3-Benzyl-5-methyl-2-pyrazinamine

3-Benzyl-5-methyl-2-pyrazinamine 1-oxide

3-Benzyl-5-p-methoxyphenyl-2-pyrazinamine

Pyrazinamines

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