1 -Benzyl-3.5-dichloro-2 -pyrazinone

I -Benzyl-3,6-dichloro-2( l//)-pyrazinonc (127, R = Cl) gave l-benzyl-5-chloro-3-methyl-2(17/)-pyrazinone (127, R = Me) [Me4Sn, Pd(PPh3)4, PhMe, reflux, <5 days residue from evaporation, KF, AcOEt, 20°C, 12 h 81%) or its 3-ethyl ho-mologues (127, R = Et) (Et4Sn, likewise 95%) 391 analogues similarly.391... [Pg.98]

Note The paucity of examples in this category is surprising. l-Benzyl-3,5-dichloro-2(l//)-pyrazinone (131) gave l-benzyl-5-chloro-3-pheny 1-2(1//)-pyrazinone (132) [PhMgBr/Et20 (made in situ), THF, -30°C, 10 min 90%].374... [Pg.99]

Benzyl-3,5-dichloro-6-phenyl-2(l//)-pyrazinone (91, R = Cl) gave 1-benzyl-5-chloro-3-(o-iodoanilino)-6-phcnyl-2(l//)-pyrazinonc (91, R = NHC6H4I-o) (H2NC6H4I-o, NaH, THF, N2, 20°C, 30 min substrate J, reflux, <5 h 78%) 1607 analogues likewise.1607 Also other examples.481,1063... [Pg.154]

Benzyl-3,6-dichloro-2(17/)-pyrazinone (127, R = Cl) gave l-benzyl-5-chloro-3-... [Pg.98]

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