Benzoyl-kallikrein

The acyl derivatives of kallikiein were prepared from porcine pancreatic kallikrein. In our experiments we used benzoyl-kallikiein, By deacylation the enzymatically active kallikrein was generated in plasma from benzoy 1-kallikrein demonstrated by means of its amidolytic activity. From the time course of reactivation of benzoy 1-kallikrein, a half-time of reactivation of 54 minutes was calculated. Benzoyl- kallikrein was protected from being inactivated by plasma inhibitors. Therefore, the kallikrein activity in nlasma was hicher after incubation... 

The effect of kallikrein and benzoyl kallikrein on kinin liberation in vivo was followed by a drop in blood pressure in rabbits (Big. 14). Kallikrein administered... 

Figure 14 Effects of i.v. injection of 0.44 nmoi/kg kallikrein (K) and benzoyl-kallikrein (BK) on mean blood pressure in rabbits. (From Ref. 43.)...

H. Muller, J. Stiirzebecher, and F. Markwardt. Benzoyl-Kallikrein Kallikreinaktivitat und Kininbildung. Biomed. Biochim. Acta 45 941 (1986). 

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