Benzotriazole Linker Units

3 Benzotriazole Linker Units. The final class of nitrogen-based linker units 

Cleavage can then be achieved by reduction to provide simple amines (Table 1.10, Entry 1), or an additional point of diversity can be introduced by treating with an appropriate nucleophile such as a Grignard reagent (Table 1.10, Entry 2) or Reformatsky reagent (Table 1.10, Entry 3). Alternatively, if carbonyl compounds are loaded onto supports via a benzotriazole, then multifunctional cleavage can be achieved by treatment with nucleophiles such as enolates or amines to provide diketones (Table 1.10, Entry 4) and ureas (Table 1.10, Entry 5), respectively. 

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