Benzothiophenes synthesis

Thiophene-2-carbaldehyde, 3-bromo-synthesis, 4, 81 Thiophenecarbaldehydes benzothiophene synthesis from, 4, 906 reactions, 4, 807 synthesis, 4, 148 Wittig reactions, 4, 807 Thiophene-2-carb aldehydes bromination, 4, 753 conformation, 4, 33 halogenation, 4, 753 reactions, 4, 72-73 reactivity, 4, 72-73 reduction, 4, 776 Thiophene-3-carb aldehydes conformation, 4, 33 reactivity, 4, 72... 

Like Larock, Flynn and co-workers utilized various electrophilic cyclization reactions to produce desirable halo-benzothiophenes for use in cross-coupling reactions. The following benzothiophene synthesis involved a Suzuki cross-coupling reaction to form new aryl-aryl bonds at the C3 position. The product has been investigated in the search for potent tubulinbinding agents. ... 

Nakamura reported a single example of the fairly efficient Rh(II)-catalyzed 4 + 1 benzothiophene synthesis, utilizing a one-pot reaction initiated by the S-H insertion of thiophenol 83 into the metallocarbenoid center derived from a-diazophosphonate 84. A subsequent base-mediated intramolecular Horner-Wadsworth-Emmons... 

Li et al. reported a tandem catalytic process employing two sequential C—S bond formations in an manner analogous to their benzothiophene synthesis (Scheme 24.42). 

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