Benzotetrazine 1,3-dioxides and 1,2,3-Benzotriazine 3-oxides

A recent report shows that 1,2,3,4-benzotetrazine 1,3-dioxide nitroderivatives 73 (R=N O2) are thiol dependent N O-donors and potent activators of the sGC [73]. Activation of the sGC was inhibited in the presence either of ODQ or of the N O scavenger 2-(4-carboxyphenyl)-4,4,5,5-tetramethy]imidazoline-l-oxyl-3-oxide (carboxy-PTIO). All products inhibited A DP-induced aggregation of human platelets, with the potency sequence 7-nitro 5,7-dinitro 5-nitro. 

A patent claims both in vitro vasodilating and sGC stimulatory NO-dependent activities for some 1,2,3-benzotriazine 3-oxide derivatives 74 [74]. Compound 74 

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