3,4-Benzopyrene oxidation

As described elsewhere in this chapter, alterations in the activity of a number of lung enzymes have been described after acute and chronic ozone exposure. With the possible exceptions of the sulfhydryl-containing enzyme succinic dehydrogenase and the cytochrome P-4 en me benzopyrene hydroxylase, it is difficult to determine whether these findings are due to a direct oxidative effect of ozone or are secondary to changes in protein synthesis, concentrations of intermediates, or destruction of cells or organelles. 

Water conjugation Water Epoxide hydrolase (microsomes) Arene oxides, cis-disubstituted and mono-substituted oxiranes Benzopyrene 7,8-epoxide, styrene 1,2-oxide, carbamazepine epoxide... 

BENZO(a)PYRENE, 3,4-BENZOPYRENE, or 6,7-BENZOPYRENE (50-32-8) Strong oxidizers may cause fires and explosions. 

Estrogens induce tumors in animals, a fact that probably depends on the formation of catechol-type A rings. Arene oxides and/or semiquinones may then be formed, which react as cross-linkers in the same way as polycyclic hydrocarbons, such as benzopyrene, which is oxidized in the body to a diol-epoxide. Electroreduction of the corresponding ortho-quimm to the semiquinone radical, the same product that would be formed upon oxygen oxidation of the catechol, in the presence of adenine, does indeed produce a covalent adduct in 14% yield (Scheme 3.4.5)... 

For example, benzopyrene benzopyrene epoxide. Alcohol oxidation... 

Other studies include the release of phenanthrene and pyrene from poly(styrene)-poly(methacrylic acid) diblock copolymer micelles > and of other copolymers such as poly(<-butyl acrylate)-poly(2-vinylpyridine) the release of benzopyrene and Cell-Tracker CM-Dil from poly(caprolactone)-poly(ethylene oxide) micelles the release of pyrene and estradiol from micelles of a EOn(eo)POn(po)EOn(eo) copol3rmer grafted with poly(acrylic acid). ... 

Figure 4.15 Time dependence of the fraction of benzopyrene released from benzopyrene-loaded poly(caprolactone)-pol3Kethylene oxide) micelles. Reproduced from Reference 91 with permission of the American Chemical Society.

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