Benzonitrile 2,6 dimethoxy

Benzonitrile, 2,6-dimethoxy-, 22, 35 Benzophenone, 23, 99 Benzophenone azine, 24, 55 Benzophenone hydrazone, 24, 54 Benzopyrrole, 23, 42 Benzothiazole, I-amino-5-methyl-,... 

Benzonitrile, 2,6-dimethoxy-, 22, 35 Benzophenone, 23, 99 Benzophenone azine, 24, 55 Benzophenone hydrazone, 24, 54 1,2-Benzopyran-3-carboxylic acid, 2-oxo-, ethyl ester, 28, 24 Benzopyrrole, 23, 42 Benzo(j) )quinolizine, 1,2,3,5,6,7-HEXAHYDRO-, 26, 40 -Benzoquinone, 26, 25 Benzothiazole, I-amino-5-methyl-, 22,16... 

Hydrogen chloride gas was passed through a solution of 2,4-dimethoxy benzonitrile (32 mmol) dissolved in 200 ml ethyl alcohol at 0°C 7 hours and the mixture stirred overnight at ambient temperature. The solvent was removed, the residue triturated in diethyl ether, and the product isolated in 57% and used without purification. 

E16d, 294 (Nitrierung) Benzonitril 2-(Dimethoxy-methyl)-E3, 357 (aus Cl/O-Acetalen)... 

Now in more specific terms, the synthesis of l-phenoxy-5-(3,5-dimethoxyphenyDpentane (4) was accomplished as follows. To a mechanically stirred Grignard reagent (prepared from 91.6 g, 0.4 mmol of 4-bromophenoxybutane and 14.6 g, 0.6 mmol of magnesium turnings in 400 mL of anhydrous THF), added 48.9 g, 0.3 mmol of 3,5-dimethoxy-benzonitrile (3) all at once and heated to reflux for 3 hours. The reaction was cooled to 0° C. with an ice bath for 15 minutes followed by the slow addition of 6N HCl (150 mL), and then allowed to stir at reflux over-... 

Die Photosubstitution von 4-Nitro-1,2-dimethoxy-benzol mit Cyanid gelingt ebenfalls in Abwcsenheit von Luftsauerstoff. Sie verlauft wie die entsprcehende alkalische Photohydrolyse unter Verdrangung der zur Xitro-Grappe meta-standigen Methoxy-Gruppe und liefert 5-Nitro-2-methoxy-benzonitrile ... 

Also obtained (poor yield) by reaction of 2,6-dimethoxy-benzonitrile with phloroglucinol in the presence of zinc chloride and hydrochloric acid in ethyl ether at 0° for 5 days, followed by hydrolysis of the resulting ketimine with boiling water for 2 h (7%) (Hoesch reaction) [439]. 

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