Benzofuranyl ether

Keywords Anti-inflammatory activity Benzofuranyl ether Coumarinyl ether Triazoles... 

The present study reports the anti-inflammatory activity of vanilhn ethers, benzofuranyl coumarins, and unsaturated cyanoesters of 4-aryloxymethyl coumarins 36. When compared with the control all the compounds showed reduction in edema volume. 

To a solution of 1.14 g of 3-methyl-trans-4a-cisoid-4a,5a-cis-5a-l,4a,5,5a,10b,10c-hexahydro-7-dioxino[5,4-a]cyclopenta[b]benzofuranyl-methanol in 10 ml of dimethoxyethane cooled in an ice bath was added 0.43 ml of anhydrous pyridine and 0.38 ml ofthionyl chloride, and the mixture was stirred for 3 hours at room temperature. After addition of ether to the reaction mixture, the precipitate was filtered, and water was added to the filtrate and the mixture was extracted three times with ether. The extract was washed with aqueous saturated solution of copper sulfate, water, aqueous saturated solution of sodium hydrogen carbonate and aqueous saturated solution of sodium chloride, dried, and concentrated to give 1.2 g of crude crystals. The crude crystals were recrystallized from ethyl acetate-hexane to yield 1 g of the pure titled chloride (m.p. 94-95°C, yield 83%). 

Hexadecanoylascorbic acid 519 Hydroquinone monoethyl ether 4860 benzofuranyl]etbanone 5298... 

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