Cations benzodithiolylium

The electrophilicity of the benzodithiolylium cation has been estimated to be between -4 and -3 on the Mayr electrophilicity scale. As such, this suggests a potential... 

The introduction of a 1,3-benzodithiol group in a stereoselective fashion can be used to generate an anionic or cationic equivalent and could be easy removed by Raney nickel. This procedure was applied to the synthesis arundic acid [34], which is currently undergoing phase II development for the treatment of acute ischemic stroke, and to the bisabolane skeleton (P. Canestrari, E. Emer, A. Gualandi, and P.G. Cozzi, unpublished results). The procedure was recently extended to the formation of quaternary stereogenic centers, in particular the alkylation of a-branched aldehydes with the benzodithiolylium ion can be catalyzed by the use of 9-amino-9-deoxy-epi-cinchona alkaloid primary amines [35]. The use of primary... 

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