1.4- Benzodiazocines, 1,2,3,4-tetrahydro

R = OMe, R1 = H), whereas reduction with sodium borohydride in methanol in the presence of sodium hydroxide gave 10,11-dimethoxy-l,2,3,4,5,6,7,8-octahydro-2,6-benzodiazocine (92) (59YZ1014). Treatment of 1,3,4,1 lb-tetrahydro-2//-pyrimido[2,l-a]isoquinoline with LAH in boil-... 

The X-ray crystallography was also utilized to determine the structure of 2,3,4,7-tetrahydro-4,7-methano-12-phenyl-l/7-cyclopenta[< ][2,3]benzodiazocine 6a (R1 = H, R2 = Ph) <2000J(P1)1139> and 7,8-diaza-l,6-di-/-butyl-2,2,5,5-tetramethyl-9-selenabicyclo[4.2.1] nonan-7-ene 7 <2000JOC1799>. 

There is only one publication reporting the synthesis of this system. Reaction of 3,4,5,6-tetrahydro-l,3-benzodiazocine-2-thione (216) with... 

Topliss reductively cyclized JV-(2-nitro-4-chlorophenyl)-JV-inethyl-2-benzo-ylbenzamide to dibenzo[b,/]-l,4-diazocine 10(67JMC642 68USP3409608). Cyclodehydration of N-(2-aminoethyl)-lV-2-(4-chlorobenzoyl)benzylben-zenesulfonamide afforded tetrahydro-2,5-benzodiazocine II (67JOC3270 70USP3496164). Cyclization of the diamino acids 12 using dicyclohexyl-carbodiimide (DCC) resulted in formation of benzodiazocines 13. Com-... 

Condensation of l,2,5,6-tetrahydro-l,6-benzodiazocine (26 R = H) with aldehydes and ketones affords bridged aminal derivatives (23 R = R = H, Me R = H, R = Ph, p-Me2N-C6H4) in good yield, with the boat conformation and relative positions of bridge substituents indicated above demonstrated by NMR spectral analysis <90MRC423>. Electrochemical reduction of dicationic diazo-... 

Ethyl chloroformate added dropwise at room temp, during 5 min. to a soln. of 3-(2-carboxyethyl)-6-chloro-4-phenyl-l,2,3,4-tetrahydroquinazoline in dry dioxane containing triethylamine, and allowed to stand an additional 15 min. at room temp. 8 - chloro -1,5 - methano - 6- phenyl -3,4,5,6- tetrahydro -1,5- benzodiazocin-... 

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