Benzo thiazol-4,7-dione

Different activity of 5-[2-(dimethylamino)ethyl]-9-phenyl-47/-benzo[,y) ]thiazolo[5,4-g]isoquinoline-4,6(5/f)-dione derivatives as photonucleases may arise from the impact of substituents on the 2-phenyl ring of thiazole on the electron population of the excited triple state according to AMI semi-empirical calculations <2004TL1247>. 

A new family of photonucleases, 5-[2-(dimethylamino)ethyl]-9-phenyl-4//-benzo[rA]thiazolo[5,4-g]isoquinoline-4,6(57/)-dione derivatives, 544, was synthesized and evaluated. These compounds intercalated into DNA efficiently and damaged DNA photochemically at concentrations as low as 5pM. Mechanistic studies suggested that a novel naphthalimide-thiazole radical produced via an excited triple state might be involved in the DNA photodamage <2004TL1247>. 

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