Benzimidazoles combinatorial library

Furthermore, a versatile and efficient microwave-promoted combinatorial library synthesis of two long alkyl chain benzimidazoles from o-substituted amines and fatty adds employing either bentonite, alumina or silica gel as solid supports has been developed [33]. Bismuth chloride [34], montmoril-lonite clay K-10 [35] and silica impregnated with sulfuric acid [36] have also... 

Dhakshinamoorthy A, Kanagaraj K, Pitchumani K (2011) Zn -KlO-clay (clayzic) as an efficient water-tolerant, solid acid catalyst for the S3Tithesis of benzimidazoles and quinoxalines at room temperature. Tetrahedron Lett 52(l) 69-73. doi 10.1016/j.tetlet.2010.10.146 Dolle RE, Bourdonnec BL, Morales GA, Moriarty KJ, Salvino JM (2006) Comprehensive survey of combinatorial library synthesis 2005. J Comb Chem 8(5) 597-635. doi 10.1021/ cc060095m... 

The principle of the split-split method is illustrated by an example of a three combinatorial step benzimidazole library that uses 24 amines, 12 o-fluoro-nitrobenzenes, and 48 acids, producing a library of 13,824 compounds (Scheme 1) (10), The first step can be performed in 24 La Marast reaction vessels, each containing 12 g of resin. For the second combinatorial step, resin from each La Marast reaction vessel is split into 24 syringes and the Domino Block synthesizer is used to handle the syringes. The last combinatorial step is performed in wells of 96-well plates, with the resin from each syringe being split into two rows (24 wells) of a plate. 

---