Benzimidazole 2-formyl

H-Azirin 2-Aminocarbonyl-3-phenyl- IV/5a, 565 Benzimidazol 2-Formyl-l-methyl-IV/la, 347... 

Dichlormethyl-benzimidazol —> 2-Formyl-benzimidazol23 Ameisensaure mit Zink- oder Eisenchlorid2,i ... 

Treatment of 2-acetyl- or 2-formyl-benzimidazole 587 with hydrazines gave the corresponding hydrazones 588, which cyclized with ethyl chloro-formate to give [84JCR(S)384] triazinobenzimidazoles 589. 

XXXVI) from this sirup have been unsuccessful. Instead, 2-formyl-5-methyl-3-furoic acid (XLIX) has been obtained. Apparently, oxidation proceeds beyond the stage of glycol cleavage, as with the benzimidazole... 

Chiral hydroxy benzimidazole 267 was dialkylated with dibromomethane or benzaldehyde dimethyl acetal to form benzo[4,5]imidazo[l,2-f]oxazoles 268 and 269 (Equation 118) C1997TA1491, 1998TA2245>. After removal of the BOC group and formylation of the liberated amine, formylaminomethylthiazole cyclized in phosphoryl chloride to... 

Not surprisingly, the formyl group at position 5 has been employed to produce thieno[2,3-, pyrimidines with no substituent at position 5 of the bicyclic product. Structures such as 372, generated from the chloropyrimidine and (benzimidazol-2-yl)methanethiol, undergo cyclization to 373 (Equation 138) <2003HC089>. 

Azobenzol 4-Formyl- IV/ld, 195 Azulen 3-Acetyl-2-amino-l-cyan-V/2c, 230 Benzimidazol... 

Pyrrole reacts with malonamides in phosphoryl chloride giving pyrroli-zines in moderate yields (Scheme 6).15 Benzimidazole-2-propionic acid undergoes cyclization and subsequent formylation under Vilsmeier conditions at room temperature (RT) (Scheme 7).16... 

The complexity of the relationship between B12 and folic acid function may extend to an interrelation between their biosyntheses. By analogy with the formation of the purine and pyrimidine rings and riboflavin (see earlier sections), one-carbon fragments may enter into the formation of the pteridine group of folic acid and of the benzimidazole group of Bi2. Further complications are the occurrence of labile one-carbon compounds attached to each the formyl group in folinic acid, and the cyano group in cyanocobalamin. There is also the possibility... 

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