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Benzazepines 3-Benzazocine

Snieckus reported a combination directed ortho-metalation (DoM)-RCM strategy for the synthesis of benzazepine, benzazocine, and benzannulated sulfonamide heterocycles <00SL1294> (Scheme 60). For example, the Boc-protected aniline (75) was sequentially allylated to give 76 which underwent RCM in excellent yield to give benzazepine 77. Use of similar methodology led to 78 and 79 starting from Y-methylbenzamide and p-tolylsulfonamide, respectively. [Pg.25]

Stereodynamic properties of medium-ring benzo-fiised nitrogenous heterocycles Benzodiazepines, benzazepines, benzazocines, and benzazo-nines 13T10783. [Pg.298]

Of current interest are the ring expansions of (2-halophenethyl)-3//-2-benzazepines, e.g. (181), in strong base (NaH-DMSO) to dibenz[6,/]benzazecines (77CPB2875) and indolo[l,2-a][3]benzazocines (78TL1209). The reaction proceeds via intramolecular ring closure of the azepine ring onto a benzyne intermediate. [Pg.528]

Treatment of 2-methyl-6,7-methylenedioxy-3,4-dihydroisoquinolinium perchlorate (126) with diazomethane afforded a mixture of aziridinium salts including 127. This underwent reaction with methanol to produce the 3-benzazocine 128.272 The 2-benzazocine 129 is obtained in a similar fashion by addition of dibromocarbene to a benzazepine.273... [Pg.146]

Methods for construction of isoindolo[l,2]-fused benzazepines and benzazocines 06KGS963. [Pg.61]

H-3-benzazepin-l(2//)-ones, 3-car-bamyl-44, 358 3-Benzazocines, 1,6-dihydro-, 2-alkoxy-5-isocyano- 43, 967 3-Benzazocin-2(li/)-ones, 3,4,5,6,-tetrahydro-, N-acyl- 44, 289 1 H-2-Benzazonines, 2,3,4,5,6,7-hexa-hydro- 43, 977 Benzene ring... [Pg.215]


See other pages where Benzazepines 3-Benzazocine is mentioned: [Pg.127]    [Pg.131]    [Pg.61]    [Pg.44]    [Pg.449]    [Pg.47]    [Pg.323]   
See also in sourсe #XX -- [ Pg.6 , Pg.469 , Pg.471 ]




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Benzazocine

Benzazocines

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