Benzalaniline Reformatsky reaction

The reaction of imines with Reformatsky reagents was first examined by Gilman and S pee ter82 in 1943 with benzalaniline. The product of the reaction was a (3-lactam, formed by cyclization of an intermediate zinc salt (Scheme IS). The stereoselectivity of the reaction of a-alkyl-substituted bromo esters with a variety of benzalanilines was examined by both Luche and Kagan,83 and Gaudemar and coworkers.84 Condensations conducted at reflux temperatures gave a mixture of cis and trans 3-lactams (equation 41). 

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See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ , ]

See also in sourсe #XX -- [ ]

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