Benign symmetric lipomatosis

LIPID AND PURINE METABOLISM IN BENIGN SYMMETRIC LIPOMATOSIS... 

The benign symmetric lipomatosis Adenolipomatosis of Launois-Bensaude (1), or Madelung s disease (2)) is characterized by multiple, symmetric deposites of subcutaneous fat on the neck, the nape, the back and upper part of the trunk. The etiology of this disease is not known in almost every published case, however, excessive alcohol consumption is common (3) In some cases this disease in accompanied by an additional diabetes (4), by hyperlipoproteinemia of type IV with elevated triglycerides and by hyperuricemia (5) ... 

Examinations of lipid and purine metabolism were only rarely undertaken. For our studies we used two patients with benign symmetric lipomatosis, one showing a symptomeless hyperuricemia ... 

Although the benign symmetric lipomatosis may be accompanied by diabetes (4), our patients did not show elevated blood glucose levels. The intravenous tolbutamide test was normal in both patients ... 

Table 3 Adenine phosphoribosyltransferase, hypoxanthine guanine phosphoribosyltransferase, and phosphoribosyl-pyrophosphate synthetase activities in hemolysates from patients with benign symmetric lipomatosis ...

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