Beauvaria bassiana

Preparative-scale Biotransformation of Sampangine by Beauvaria bassiana... 

A preparative-scale biotransformation of sampangine was performed with Beauvaria bassiana ATCC 7159 using the standard two-stage fermentation procedure. This afforded a pure red metabolite (33 mg, 9.7% yield) (Fig. (5)). 

The product can be spread on trays and dried in a flow hood [ 196]. However, note that drying operations can readily be carried out in the bioreactor if packed beds are used. All that is necessary is to change the conditions of the inlet air [195]. For the production of Beauvaria bassiana on clay microgranules, which are well suited to direct harvesting and drying without further formulation, Desgranges et al. [197] increased the air flow rate twofold and decreased the relative humidity of the inlet air to 17%. 

FIGURE 15.49 Biotransformation of eudesmenone (152a) by Beauvaria bassiana. 

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