Basket-type bioreactor

Kalogerakis, N. and L.A. Behie, "Oxygenation Capabilities of New Basket-Type Bioreactors for Microcarrier Cultures of Anchorage Dependent Cells", Bioprocess Eng., 17, 151-156(1997). 

Mechanical properties and control of particle size are the main drawbacks of CLEAs. Particles are compressible and shear sensitive and size is usually small so that recovery of the biocatalyst may pose a problem for conventional reactor configurations (see Chapter 5). To solve that problem, basket-type bioreactors can be used or else the biocatalyst can be modified. An interesting approach is the encapsulation of CLEAs within polymer gels, as shown in Fig. 4.4c. Entrapment of CLEAs within polyvinyl alcohol lens-shaped gel particles (LentiKats) produced very robust biocatalysts of a convenient size to be easily recovered (Wilson et al. 2004c). 

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