Basicity of organic bases

The inductive effect of fluorination also reduces the basicity of organic bases by approximately the same order of magnitude (Table 1.6). In contrast with basicity, the nucleophilicity of amines is influenced much less by fluorinated substituents. 

Acidity of organic acids (and/or basicity of organic bases) such as carboxylic acid and amines is governed by many factors solvent, substitution, conformation and so forth. Amongst those factors the effect of conformational change is of special interest in terms of its significance... 

Z. Glasovac, M. Eckert-Maksid, and Z.B. Maksid, Basicity of organic bases and superbases in acetonitrile by the polarized continuum model and DFT calculations, New J. Chem. 33 (2009), pp. 588-597. 

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