Based Chiral Ligands in C-F Bond Forming Reactions

Cinchona-Based Chiral Ligands in C F Bond Forming Reactions 

The quest for methods of synthesizing chiral fluoroorganic compounds is one of the most fascinating topics in modern organofluorine chemistry because the replacement of hydrogen with a fluorine atom often results in a significant improvement in the physicochemical properties and biological activities of the molecules. 

A variety of highly enantioselective chiral N-F fluorinating reagents derived from Cinchona alkaloids were developed for the direct enantioselective fluorination of C—H acidic substrates (for details, see Chapter 6). Simultaneously, metal-catalyzed 

This chapter has presented the current stage in the development of metal-promoted asymmetric C—C and C—X bond forming reactions, in which cinchona alkaloids are utilized as chirality inducers. As shown in many of the examples discussed above, cinchona alkaloids and their derivatives have great potential to serve as chiral ligands or cobase catalysts in diverse metal-promoted asymmetric C—C and C—X bond forming reactions. However, despite the scientific achievements that have been made 

This work was supported by grants KRF-2008-005-J00701 (MOEHRD), Rll-2005-008-00000-0 (SRC program of MEST/KOSEF) and R31-2008-000-10029-0 (WCU program). 

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