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Base-pairing paradox

Several hypotheses have been developed in order to interpret the paradox of a degenerate code and the specific synthesis of proteins. The wobble theory of Crick (1966 a) postulates the possibility of alternate ways of pairing between the bases of the w-RNA and -RNA. Within the framework of this theory it is assumed that the pairing for the two first positions of each codon-anticodon pair is normal, A <—>TJ, C <—>G. But in order to explain the multiple correspondence it is necessary to assume other possibilities of pairing for the third position. The postulated rela-... [Pg.46]


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