Tibolone Barbiturates

BARBITURATES TIBOLONE 1 tibolone levels Induction of metabolism of tibolone Watch for poor response to tibolone consider increasing its dose... 

The manufacturer says that on a theoretical basis enzyme inducers such as the barbiturates, carbamazepine, phenytoin and rifampicin may accelerate the metabolism of tibolone and thus decrease its efficacy. However, they note that no examples of these interactions have been reported in clinical practice, and pharmacokinetic studies are required to demonstrate this interaction. Nevertheless it would be prudent to monitor concurrent use. 

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