BANAs. neuraminidase inhibitors

Based on the lead compound BANA 113 42, which inhibits influenza A neuraminidase with a Ki of 2.5 p.M [91a,b], several novel 2-pyrrolidinone derivatives were designed. Whereas compound 43 (BANA 205) is a relatively weak inhibitor of influenza A and B neuraminidases, with IC50 values in the low micromolar range, compound 44 (BANA 206) is much more potent, with an IC50 value of 48 nM against influenza A neuraminidase. However, this compound is not as potent against influenza B virus sialidase [91d,e]. 

FIGURE 16.13 The BANAs, a class of hydrophobic benzoic acid derivatives, acting as potent inhibitors of influenza neuraminidase. 

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See also in sourсe #XX -- [ ]

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