Balance study protocols, effect

One effective method of obtaining information about zinc metabolism Is the use of radioactive tracers to study absorption, kinetics and body distribution following oral administration. Of course, as in all cases in which radionuclides are administered to human subjects, the hazard of such administration must be considered and balanced against the value of information expected from the study. The administered activity should be as low as possible consistent with obtaining adequate measurements. The studies reported here were carried out in accordance with approved protocols which followed relevant guidelines for studies of human subjects and with the informed consent of the participating subjects. 

Although MTBE is not classified as an eye irritant [3], there have been small effects noted in several of the studies conducted [66-69]. Among three studies for eye irritation in rabbits conducted to OECD protocols, the balance of the evidence is that ETBE is not an eye irritant. In one study, some conjunctival redness and chemosis was recorded in all rabbits soon after ap-phcation of the undiluted material [70], but in two other studies in rabbits, conjunctival responses were minimal and no iridial or corneal effects were observed [71,72]. 

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